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Sterile fill-finish capacity is constrained and shared across many products competing for the same lines

This suggests the significance of the hydrophobic nature of the interface in the FOXO4 FHD and p53 TAD interaction

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It should be used temporarily until diagnostic workup confirms a specific type

This movement combined with the change in charge introduced by the mutations modifies the binding cavity, forcing glutathione to adopt a nonproductive binding mode and permitting trypanothione and to a certain degree also the weak substrate glutathionylspermidine to assume a productive mode

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